![]() ![]() Pharmacological inhibition of IDOL activity in the brain may represent a therapeutic strategy for the treatment of AD. Our results suggest that reducing IDOL expression in the adult brain promotes the phagocytic clearance of Aβ and ameliorates Aβ-dependent pathology. Furthermore, clustering of microglia revealed that IDOL-ASO treatment shifted the composition of the microglia population by increasing the prevalence of disease-associated microglia. Ouat Jefferson x reader Tumblr Sebastian Stan, Marvel Actors, Marvel Dc, Winter. Single-cell transcriptomic analysis of hippocampus revealed that IDOL inhibition upregulated lysosomal/phagocytic genes in microglia. ASO treatment led to decreased Aβ pathology and improved spatial learning and memory. Romanov RA, Zeisel A, Bakker J, Girach F, Hellysaz A, Tomer R, Alpr A, Mulder J, Clotman F, Keimpema E, Hsueh B. Hey, sorry to reply on this thread the other was locked to comments, go ahead and request access to the tsopm7.bin again. 2: Dissolution of Eternity by Rogue Entertainment) Edit: Added a lot of new info and download links. In this study, we utilized an antisense oligonucleotide (ASO) to reduce IDOL expression therapeutically in the brains of APP/PS1 male mice. QuakeROGUEPAK0.PAK (Edit: Quake Mission Pack No. Genetic ablation of Idol increases low-density lipoprotein receptor protein levels, which facilitates Aβ uptake and clearance by microglia. Previously, we identified E3 ubiquitin ligase IDOL as a negative regulator of brain lipoprotein receptors. Brain lipoprotein receptors have been shown to regulate the metabolism of ApoE and β-amyloid (Aβ) and are potential therapeutic targets for Alzheimer’s disease (AD).
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